Endocrine Abstracts

Background: Few cases of hypersensitivity of thyroid–pituitary feedback in hypothyroid children were reported.Aim: To present a family with asymptomatic, severe biochemical primary autoimmune hypothyroidism who showed a marked sensitivity of pituitary feedback to levothyroxine treatment.Methods: TSH was measured by 3rd generation immunoassay kit.Case report: R.G, woman, aged 22, presented for asymptomati...

Objective: To assess the outcome of medical and ablative therapies in amiodarone-induced thyrotoxicosis (AIT).Subjects and methods: Seventy patients (32 M/38 F, aged 59.7±1.4 years) with AIT (24-type 1, 20-type 2 and 26-mixed forms) were followed-up 13.4±2.3 months. TSH was measured by immunoradiometric assay, TT3 and TT4 by chemiluminescence.Results: Antithyroid drugs (ATD) were used as single thera...

Introduction: Primary amenorrhea is defined as the absence of menses at age 15 years in the presence of normal growth and secondary sexual characteristics, or at 13 years, if there is no breast development. We retrospectively assessed the causes of primary amenorrhea in a series from an academic center of adult endocrinology.Patients and methods: We retrieved data from the files of 111 consecutive patients with primary amenorrhea evaluated in our center ...

Aim: To assess cumulative incidence and risk factors for amiodarone-induced thyroid dysfunction (AITD) in a large cohort of Romanian subjects.Subjects and methods: One hundred and forty-four patients (59 M/85 F), mean age 61.4±0.9 years, treated 2.4±0.2 years with amiodarone were assessed for TSH, TT3, TT4 (immunoradiometric assays) and FT4, TPO Ab (microenzymatic immunoassays). Thirty-three patients were reside...

Acromegaly control/remission is defined by stringent criteria: normal age-/sex-adjusted IGF1 and random GH (GHr) <1 ng/ml or a GH nadir (GHn) during oral glucose tolerance test (OGTT) of <0.4 ng/ml. However discordances between GH and IGF1 have been recorded in about 30% of patients. We retrospectively analyzed the evolution in patients with acromegaly and discordant GH–IGF1 levels while being treated with somatostatin analogs (SSA) and/or cabergoline (CAB).<p...

Background: Hyponatremia is a common electrolyte abnormality, especially in elderly, hospitalized patients, with a prevalence of severe hyponatremia (<125 mmol/l) up to 6–8%. Pituitary insufficiency (TSH+ACTH) may be difficult to diagnose, but it is important to differentiate it from SIADH and cerebral salt wasting syndrome.Aim: To describe the aetiology and outcome of patients with hyponatremia due to pituitary insufficiency in a tertiary endoc...

Background: Endocrine hypertension accounts for around 3% of the secondary forms of hypertension and screening of young hypertensive patients for secondary causes is mandatory.Aim: To present difficulties in endocrine assessment of arterial hypertension in people younger than 40 years.Patients and methods: Twenty-two patients (15 M/7 F), aged 27.1±7.7 years (range:16-40 years), with systemic hypertension (systolic blood pressu...

Background: Thermoregulatory disorders after neurosurgery of craniopharingyomas were seldom reported.Aim: To present the difficulties of etiologic diagnosis and treatment of a persistent febrile syndrome in a patient with surgically removed craniopharyngioma.Patient and methods: A 34 years old man with a giant craniopharyngioma situated in the basal-anterior part of the third ventricle is reported. Anterior pituitary hormones were ...

Pituitary apoplexy is a rare syndrome due to a clinically overt hemorrhagic infarction, described in 2–7% of pituitary adenomas. A subclinical usually asymptomatic pituitary hemorrhage and/or infarction may be detected on routine imaging or during histopathological examination in 25–28% of patients with pituitary adenomas.Aim: We compared the clinical features and evolution of 166 patients with subclinical pituitary apoplexy (SPA) and 46 patien...

Background: In patients with acromegaly, mortality depends most on achievement of control of GH/IGF1 levels. However, some of the complications of acromegaly still develop, despite successful control of disease. The aim of the study is to correlate mortality and morbidity with cumulative GH exposure in these patients compared to last GH/IGF1 level.Methods: We studied retrospectively 336 patients with acromegaly consecutively evaluated at least twice duri...